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| Profile Name | HRAS G13R SRC T341M |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| HRAS G13R SRC T341M | thyroid cancer | sensitive | Trametinib | Preclinical - Cell culture | Actionable | In a preclinical study, Mekinist (trametinib) inhibited growth of a Sprycel (dasatinib)-resistant thyroid cancer cell line harboring HRAS G13R and an acquired SRC T341M mutation in culture (PMID: 27222538). | 27222538 | |
| HRAS G13R SRC T341M | thyroid cancer | resistant | Dasatinib | Preclinical - Cell culture | Actionable | In a preclinical study, a thyroid cancer cell line harboring HRAS G13R and an acquired SRC T341M mutation demonstrated resistance to Sprycel (dasatinib) in culture (PMID: 27222538). | 27222538 | |
| HRAS G13R SRC T341M | thyroid cancer | sensitive | Selumetinib | Preclinical - Cell culture | Actionable | In a preclinical study, Koselugo (selumetinib) inhibited growth of a Sprycel (dasatinib)-resistant thyroid cancer cell line harboring HRAS G13R and an acquired SRC T341M mutation in culture (PMID: 27222538). | 27222538 |