Molecular Profile Detail

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Profile Name FLT3 exon 14 ins FLT3 D835X NRAS Q61K
Gene Variant Detail

FLT3 D835X (unknown)

FLT3 exon 14 ins (gain of function - predicted)

NRAS Q61K (loss of function - predicted)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 D835X NRAS Q61K acute myeloid leukemia predicted - resistant Gilteritinib Case Reports/Case Series Actionable In a clinical study, two patients with acute myeloid leukemia harboring FLT3-ITD and a D835 mutation progressed on Xospata (gilteritinib) treatment and were found to have acquired NRAS Q61K (PMID: 31088841). 31088841