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| Profile Name | IDH1 R132H IDH1 D279N |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| IDH1 R132H IDH1 D279N | acute myeloid leukemia | predicted - resistant | Ivosidenib | Preclinical - Cell culture | Actionable | In a preclinical study, Tibsovo (ivosidenib) modestly suppressed (R)-2-hydroxyglutarate (R-2HG) production in an acute myeloid leukemia cell line expressing IDH1 R132H and D279N but did not inhibit cytokine-independent growth in culture (PMID: 36056177). | 36056177 | |
| IDH1 R132H IDH1 D279N | acute myeloid leukemia | sensitive | LY3410738 | Preclinical - Cell culture | Actionable | In a preclinical study, LY3410738 inhibited (R)-2-hydroxyglutarate (R-2HG) production and cytokine-independent growth in an acute myeloid leukemia cell line expressing IDH1 R132H and D279N in culture (PMID: 36056177). | 36056177 |