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| Profile Name | ERBB3 D297H |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| ERBB3 D297H | head and neck squamous cell carcinoma | sensitive | Neratinib | Preclinical - Cell culture | Actionable | In a preclinical study, Nerlynx (neratinib) treatment inhibited viability of a hypopharyngeal squamous cell carcinoma cell line harboring ERBB3 (HER3) D297H in culture (PMID: 33473169). | 33473169 | |
| ERBB3 D297H | head and neck squamous cell carcinoma | sensitive | Lapatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Tykerb (lapatinib) treatment inhibited viability of a hypopharyngeal squamous cell carcinoma cell line harboring ERBB3 (HER3) D297H in culture (PMID: 33473169). | 33473169 |