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| Profile Name | POLD1 L474P |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| POLD1 L474P | melanoma | sensitive | unspecified PD-1 antibody | Preclinical | Actionable | In a preclinical study, a murine anti-PD1 antibody inhibited tumor growth in a syngeneic mouse model of melanoma expressing POLD1 L474P (corresponds to L472P in mouse) (PMID: 35817971). | 35817971 |