Molecular Profile Detail

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Profile Name PIK3CA E542Q PIK3CA E674Q
Gene Variant Detail

PIK3CA E542Q (unknown)

PIK3CA E674Q (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E542Q PIK3CA E674Q urinary bladder cancer sensitive Alpelisib + Nintedanib Preclinical - Cell line xenograft Actionable In a preclinical study, combination treatment with Ofev (nintedanib) and Piqray (alpelisib) led to synergistic inhibition of growth in bladder cancer cell lines harboring PIK3CA E542Q and PIK3CA E674Q in culture, and led to inhibition of tumor growth in a cell line xenograft model (PMID: 36805958). 36805958
PIK3CA E542Q PIK3CA E674Q urinary bladder cancer sensitive Nintedanib + Pictilisib Preclinical - Cell culture Actionable In a preclinical study, combination treatment with Ofev (nintedanib) and Pictilisib (GDC-0941) inhibited cell proliferation in a bladder cancer cell line harboring PIK3CA E542Q and PIK3CA E674Q in culture (PMID: 36805958). 36805958