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| Profile Name | FGFR3 S249C FGFR3 N540K |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| FGFR3 S249C FGFR3 N540K | intrahepatic cholangiocarcinoma | predicted - sensitive | Futibatinib | Preclinical - Cell culture | Actionable | In a preclinical study, Lytgobi (futibatinib) inhibited viability of a bladder cancer cell line harboring FGFR3 S249C and expressing FGFR3 N540K in culture (PMID: 38437671). | 38437671 | |
| FGFR3 S249C FGFR3 N540K | urinary bladder cancer | resistant | Pemigatinib | Preclinical - Cell culture | Actionable | In a preclinical study, a bladder cancer cell line harboring FGFR3 S249C and expressing FGFR3 N540K was resistant to Pemazyre (pemigatinib) in culture (PMID: 38437671). | 38437671 | |
| FGFR3 S249C FGFR3 N540K | urinary bladder cancer | sensitive | KIN-3248 | Preclinical - Cell culture | Actionable | In a preclinical study, KIN-3248 inhibited viability of a bladder cancer cell line harboring FGFR3 S249C and expressing FGFR3 N540K in culture (PMID: 38437671). | 38437671 |