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Profile Name | DNMT3A loss FLT3 exon 14 ins |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
DNMT3A loss FLT3 exon 14 ins | acute myeloid leukemia | no benefit | Quizartinib + Talazoparib | Preclinical - Cell culture | Actionable | In a preclinical study, the addition of Talzenna (talazaparib) did not enhance the sensitivity of mouse acute myeloid leukemia cells harboring a FLT3-ITD mutation and DNMT3A loss to Vanflyta (quizartinib) treatment compared to Vanflyta (quizartinib) alone in culture (PMID: 34215619). | 34215619 |