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Profile Name | JAK2 V617F TET2 loss |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
JAK2 V617F TET2 loss | acute myeloid leukemia | sensitive | Olaparib + Rituximab | Preclinical - Cell culture | Actionable | In a preclinical study, treatment with the combination of Lynparza (olaparib) and Rituxan (rituximab) decreased colony formation in mouse acute myeloid leukemia cells harboring JAK2 V617F and TET2 loss in culture (PMID: 34215619). | 34215619 | |
JAK2 V617F TET2 loss | acute myeloid leukemia | sensitive | Hydroxyurea + Olaparib + Rituximab | Preclinical - Cell culture | Actionable | In a preclinical study, Lynparza (olaparib), Droxia (hydroxyurea), and Rituxan (rituximab) combination treatment decreased colony formation in mouse acute myeloid leukemia cells harboring JAK2 V617F and TET2 loss in culture (PMID: 34215619). | 34215619 |