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Molecular Profile Detail

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Profile Name PIK3CA E453K PIK3CA E545A
Gene Variant Detail

PIK3CA E453K (gain of function)

PIK3CA E545A (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA E453K PIK3CA E545A stomach cancer sensitive Alpelisib Preclinical - Cell culture Actionable In a preclinical study, Piqray (alpelisib) inhibited growth and induced cell cycle arrest and inhibited phosphorylation of Akt and S6 in a gastric cancer cell line harboring PIK3CA E545A and E453K in culture (PMID: 37493631). 37493631
PIK3CA E453K PIK3CA E545A stomach cancer sensitive Alpelisib + Dasatinib Preclinical - Cell culture Actionable In a preclinical study, the addition of Sprycel (dasatinib) to Piqray (alpelisib) treatment resulted in an increased inhibition of proliferation in a gastric cancer cell line harboring PIK3CA E545A and E453K in culture (PMID: 37493631). 37493631
PIK3CA E453K PIK3CA E545A stomach cancer sensitive A-1331852 + Alpelisib Preclinical - Cell culture Actionable In a preclinical study, the combination of Piqray (alpelisib) and A-1331852 synergistically inhibited viability in a gastric cancer cell line harboring PIK3CA E545A and E453K in culture (PMID: 37493631). 37493631