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Profile Name | APC E633* APC E1494* APC Q1529* |
Gene Variant Detail |
APC E1494* (loss of function - predicted) |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
APC E633* APC E1494* APC Q1529* | colorectal cancer | sensitive | G007-LK | Preclinical - Cell culture | Actionable | In a preclinical study, G007-LK inhibited viability of a patient-derived colorectal cancer cell line harboring APC E1494*, E633*, and Q1529* in culture (PMID: 37968472). | 37968472 |