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| Profile Name | PBRM1 inact mut VHL loss |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| PBRM1 inact mut VHL loss | clear cell renal cell carcinoma | sensitive | Belzutifan + PRT1419 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of PRT1419 and Welireg (belzutifan) inhibited tumor growth of a clear cell renal cell carcinoma cell line xenograft model harboring an inactivating PBRM1 mutation and with loss of VHL (PMID: 38371625). | 38371625 |