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Profile Name ERBB3 G284R
Gene Variant Detail

ERBB3 G284R (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ERBB3 G284R Advanced Solid Tumor sensitive Lapatinib Preclinical Actionable In a preclinical study, Tykerb (lapatinib) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) G284R (PMID: 23680147). 23680147
ERBB3 G284R Advanced Solid Tumor sensitive Duligotuzumab Preclinical Actionable In a preclinical study, MEHD7945A inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) G284R (PMID: 23680147). 23680147
ERBB3 G284R Advanced Solid Tumor sensitive Trastuzumab Preclinical Actionable In a preclinical study, Herceptin (trastuzumab) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) G284R (PMID: 23680147). 23680147
ERBB3 G284R Advanced Solid Tumor sensitive Pertuzumab Preclinical Actionable In a preclinical study, Perjeta (pertuzumab) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) G284R (PMID: 23680147). 23680147
ERBB3 G284R Advanced Solid Tumor resistant Cetuximab Preclinical Actionable In a preclinical study, transformed cell lines expressing ERBB3 (HER3) G284R demonstrated resistance to treatment with Erbitux (cetuximab) (PMID: 23680147). 23680147
ERBB3 G284R Advanced Solid Tumor sensitive Pictilisib Preclinical Actionable In a preclinical study, the PI3K inhibitor GDC-0941 inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) G284R (PMID: 23680147). 23680147
ERBB3 G284R Advanced Solid Tumor sensitive Mirdametinib + Pictilisib Preclinical Actionable In a preclinical study, the combination of GDC-0941 and Gomekli (mirdametinib) inhibited proliferation and colony formation in transformed cell lines expressing ERBB3 (HER3) G284R (PMID: 23680147). 23680147
ERBB3 G284R transitional cell carcinoma sensitive Afatinib Case Reports/Case Series Actionable In a Phase II trial, a patient with urothelial carcinioma harboring ERBB3 G284R demonstrated stable disease for 7 months when treated with Gilotrif (afatinib) (J Clin Oncol 33, 2015 (suppl 7; abstr 312)). detail...
ERBB3 G284R urinary bladder cancer sensitive Afatinib Case Reports/Case Series Actionable In a Phase II clinical trial, a patient with ERBB3 G284R mutant urothelial carcinoma had improved progression free survival when treated with Gilotrif (afatinib), and median PFS was 6.6 months for patients with ERBB2 or ERBB3 alterations relative to 1.4 months for patients lacking alterations (PMID: 27044931). 27044931
ERBB3 G284R breast cancer predicted - sensitive Lapatinib + Trastuzumab Case Reports/Case Series Actionable In a clinical case study, the combination treatment of Herceptin (trastuzumab) and Tykerb (lapatinib) in a patient with breast cancer harboring ERBB3 (HER3) G284R resulted in antitumor efficacy, demonstrating a complete metabolic response after day 14 of treatment, a partial response after 8 weeks of treatment, and no clinical evidence of disease after 40 weeks of treatment (PMID: 25953157). 25953157
ERBB3 G284R breast cancer sensitive Patritumab deruxtecan Preclinical - Cell culture Actionable In a preclinical study, Patritumab deruxtecan (U3-1402) treatment inhibited growth of a breast cancer cell line expressing ERBB3 (HER3) G284R in culture (PMID: 35503762). 35503762
ERBB3 G284R Her2-receptor positive breast cancer predicted - sensitive Neratinib + Palbociclib Case Reports/Case Series Actionable In a Phase I trial, treatment with the combination of Nerlynx (neratinib) and Ibrance (palbociclib) resulted in an objective response rate of 16.7% (5/30, all partial responses) and clinical benefit rate of 26.7% in patients with advanced solid tumors harboring HER alterations, including a partial response in a patient with ESR1-positive, ERBB2 (HER2)-positive breast cancer harboring ERBB3 G284R (PMID: 41223631; NCT03065387). 41223631