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Profile Name | FGFR2 I291_Y308del FGFR2 N549K |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
FGFR2 I291_Y308del FGFR2 N549K | cholangiocarcinoma | predicted - resistant | Pemigatinib | Case Reports/Case Series | Actionable | In a Phase II trial (FIGHT-207), FGFR2 N549K was identified in the post-progression circulating tumor DNA of a patient with cholangiocarcinoma harboring FGFR2 I291_Y308del who previously responded to Pemazyre (pemigatinib) treatment (PMID: 38710951; NCT03822117). | 38710951 |