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Profile Name | BRAF del exon2-10 BRAF V600E |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
BRAF del exon2-10 BRAF V600E | melanoma | predicted - resistant | Vemurafenib | Case Reports/Case Series | Actionable | In a clinical case study, a deletion of BRAF exons 2-10 was identified in the post-progression biopsy of three melanoma patients harboring BRAF V600E who were treated with Zelboraf (vemurafenib) (PMID: 22113612). | 22113612 |