Molecular Profile Detail

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Profile Name EML4 - ALK ALK L1122V ALK L1196M ALK D1203N ALK G1269A
Gene Variant Detail

ALK D1203N (unknown)

ALK G1269A (unknown)

ALK L1122V (unknown)

ALK L1196M (gain of function)

EML4 - ALK (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
EML4 - ALK ALK L1122V ALK L1196M ALK D1203N ALK G1269A lung adenocarcinoma predicted - resistant Ceritinib Case Reports/Case Series Actionable In a clinical case study, ALK D1203N and L1122V were identified in post-progression biopsy in a patient with metastatic lung adenocarcinoma harboring EML4-ALK, ALK G1269A, and ALK L1196M, who previously achieved a partial response on Zykadia (ceritinib) treatment (PMID: 38961982). 38961982