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Profile Name | JAK1 V658F JAK1 L929Q |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
JAK1 V658F JAK1 L929Q | hematologic cancer | predicted - resistant | Ruxolitinib | Preclinical - Cell culture | Actionable | In a preclinical study, a cell line expressing JAK1 V658F and L929Q was moderately resistant to Jakafi (ruxolitinib) in culture (PMID: 39091915). | 39091915 |