Molecular Profile Detail

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Profile Name HRAS G13R PTEN loss
Gene Variant Detail

HRAS G13R (loss of function - predicted)

PTEN loss (loss of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
HRAS G13R PTEN loss Advanced Solid Tumor resistant AZD8186 Preclinical - Cell culture Actionable In a preclinical study, HRAS-null, NRAS-null, and KRAS knockout cells with PTEN loss and expressing HRAS G13R were not sensitive to treatment with AZD8186 in culture (PMID: 39152269). 39152269
HRAS G13R PTEN loss Advanced Solid Tumor resistant Pictilisib Preclinical - Cell culture Actionable In a preclinical study, HRAS-null, NRAS-null, and KRAS knockout cells with PTEN loss and expressing HRAS G13R were not sensitive to treatment with Pictilisib (GDC-0941) in culture (PMID: 39152269). 39152269