Molecular Profile Detail

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Profile Name JAK3 Q988P
Gene Variant Detail

JAK3 Q988P (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK3 Q988P hematologic cancer sensitive LGH447 Preclinical - Cell culture Actionable In a preclinical study, LGH447 inhibited viability and proliferation of transformed cells expressing JAK3 Q988P in culture (PMID: 39033228). 39033228
JAK3 Q988P hematologic cancer decreased response Ruxolitinib Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing JAK3 Q988P were less sensitive to Jakafi (ruxolitinib) treatment compared to cells expressing JAK3 M511I in culture (PMID: 37712558). 37712558
JAK3 Q988P hematologic cancer sensitive Tofacitinib Preclinical - Cell culture Actionable In a preclinical study, Xeljanz (tofacitinib) inhibited growth of transformed cells expressing JAK3 Q988P in culture (PMID: 37712558). 37712558