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| Profile Name | CSF1R F563_P566del |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| CSF1R F563_P566del | Erdheim-Chester disease | predicted - resistant | Pexidartinib | Case Reports/Case Series | Actionable | In a clinical case study, CSF1R F563_P566del was identified at the time of progression, along with loss of the original CSF1R S560_P566del and S938_Y969del mutations, in a patient with Erheim-Chester disease, who originally achieved a partial response with Turalio (pexidartinib) treatment (PMID: 39576953). | 39576953 |