Molecular Profile Detail

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Profile Name FGFR2 C383R FGFR2 N550D FGFR2 N550K FGFR2 V565L
Gene Variant Detail

FGFR2 C383R (unknown)

FGFR2 N550D (unknown)

FGFR2 N550K (gain of function)

FGFR2 V565L (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 C383R FGFR2 N550D FGFR2 N550K FGFR2 V565L cholangiocarcinoma predicted - resistant Erdafitinib Case Reports/Case Series Actionable In a retrospective analysis, a cholangiocarcinoma patient harboring FGFR2 C383R progressed on treatment with Balversa (erdafitinib) and was found to have acquired FGFR2 N550K and V565L via cell-free DNA, and FGFR2 N550D via cell-free DNA and tissue biopsy (PMID: 39706336; NCT01703481). 39706336