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| Profile Name | ARID1A Q909* |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| ARID1A Q909* | skin melanoma | predicted - sensitive | Niraparib | Case Reports/Case Series | Actionable | In a Phase II clinical trial, Zejula (niraparib) therapy demonstrated activity in melanoma patients harboring mutations in HRR pathway genes, resulting in a partial response (PR) rate of 14% (2/14) and disease control rate (DCR) of 64% (9/14), with stable disease in 7 patients and a median progression-free survival of 16 weeks; response rate was 20% (2/10, 2 PR) and DCR was 70% (7/10) in patients with non-uveal melanoma, including a PR in a cutaneous melanoma patient harboring ARID1A Q909* (PMID: 40373259). | 40373259 |