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| Profile Name | ALK rearrange ALK G1202R ALK R1275L |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| ALK rearrange ALK G1202R ALK R1275L | lung non-small cell carcinoma | predicted - resistant | Alectinib | Case Reports/Case Series | Actionable | In a retrospective analysis of a Phase III trial (J-ALEX), ALK G1202R and ALK R1275L were identified in the post-progression cell-free DNA of a patient with non-small cell lung cancer with ALK rearrangement who progressed on treatment with Alecensa (alectinib) (PMID: 40912045). | 40912045 |