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| Profile Name | FLT3 V491L |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| FLT3 V491L | acute myeloid leukemia | sensitive | Gilteritinib | Case Reports/Case Series | Actionable | In a clinical case study, Xospata (gilteritinib) treatment resulted in disappearance of peripheral blasts in a patient with acute myeloid leukemia harboring FLT3 V491L, and in a preclinical study, inhibited viability of patient-derived acute myeloid leukemia cells in culture (PMID: 41487332). | 41487332 |