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| Profile Name | JAK2 S755R JAK2 R938Q |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| JAK2 S755R JAK2 R938Q | hematologic cancer | decreased response | AZ960 | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing JAK2 S755R and R938Q demonstrated decreased response to AZ960 in culture (PMID: 24398328). | 24398328 | |
| JAK2 S755R JAK2 R938Q | hematologic cancer | decreased response | Fedratinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing JAK2 S755R and R938Q demonstrated decreased response to Inrebic (fedratinib) in culture (PMID: 24398328). | 24398328 | |
| JAK2 S755R JAK2 R938Q | hematologic cancer | decreased response | Luminespib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing JAK2 S755R and R938Q demonstrated decreased response to Luminespib (AUY922) in culture (PMID: 24398328). | 24398328 | |
| JAK2 S755R JAK2 R938Q | hematologic cancer | decreased response | Ruxolitinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing JAK2 S755R and R938Q demonstrated decreased response to Jakafi (ruxolitinib) in culture (PMID: 24398328). | 24398328 | |
| JAK2 S755R JAK2 R938Q | hematologic cancer | decreased response | Momelotinib | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing JAK2 S755R and R938Q demonstrated decreased response to Momelotinib (CYT387) in culture (PMID: 24398328). | 24398328 | |
| JAK2 S755R JAK2 R938Q | hematologic cancer | sensitive | LY294002 | Preclinical - Cell culture | Actionable | In a preclinical study, LY294002 inhibited growth of cells expressing JAK2 S755R and R938Q in culture (PMID: 24398328). | 24398328 |