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Profile Name | JAK2 V617F JAK2 E864K |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
JAK2 V617F JAK2 E864K | hematologic cancer | resistant | NVP-BSK805 | Preclinical - Cell culture | Actionable | In a preclinical study, immune cells expressing the JAK2 V617F and JAK2 E864K double mutation demonstrated resistance to NVP-BSK805 in culture (PMID: 22271575). | 22271575 | |
JAK2 V617F JAK2 E864K | hematologic cancer | resistant | NVP-BVB808 | Preclinical | Actionable | In a preclinical study, immune cells expressing the JAK2 V617F and JAK2 E864K double mutation demonstrated resistance to NVP-BVB808 in culture (PMID: 22271575). | 22271575 |