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| Profile Name | JAK2 R683G JAK2 E864K |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| JAK2 R683G JAK2 E864K | cancer | resistant | NVP-BSK805 | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing the JAK2 R683G/E864K double mutation demonstrated resistance to NVP-BSK805 in culture (PMID: 22271575). | 22271575 | |
| JAK2 R683G JAK2 E864K | cancer | resistant | NVP-BVB808 | Preclinical | Actionable | In a preclinical study, cells expressing the JAK2 R683G/E864K double mutation demonstrated resistance to NVP-BVB808 in culture (PMID: 22271575). | 22271575 |