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Profile Name | JAK2 R683G JAK2 G935R |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
JAK2 R683G JAK2 G935R | cancer | resistant | Ruxolitinib | Preclinical | Actionable | In a preclinical study, cells expressing the JAK2 R683G/G935R double mutation demonstrated resistance to Jakafi (Ruxolitinib) in culture (PMID: 22271575). | 22271575 | |
JAK2 R683G JAK2 G935R | cancer | resistant | NVP-BSK805 | Preclinical - Cell culture | Actionable | In a preclinical study, cells expressing the JAK2 R683G/G935R double mutation demonstrated resistance to NVP-BSK805 in culture (PMID: 22271575). | 22271575 | |
JAK2 R683G JAK2 G935R | cancer | resistant | NVP-BVB808 | Preclinical | Actionable | In a preclinical study, cells expressing the JAK2 R683G/G935R double mutation demonstrated resistance to NVP-BVB808 in culture (PMID: 22271575). | 22271575 |