Molecular Profile Detail

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Profile Name JAK3 V718L
Gene Variant Detail

JAK3 V718L (unknown)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
JAK3 V718L esophagus adenocarcinoma sensitive Pacritinib Preclinical - Patient cell culture Actionable In a preclinical study, Vonjo (pacritinib) inhibited viability of cells derived from the brain metastases of a patient with esophagus adenocarcinoma harboring JAK3 V718L in culture (PMID: 38985431). 38985431
JAK3 V718L esophagus adenocarcinoma sensitive Quizartinib Preclinical - Patient cell culture Actionable In a preclinical study, Vanflyta (quizartinib) inhibited viability of cells derived from the brain metastases of a patient with esophagus adenocarcinoma harboring JAK3 V718L in culture (PMID: 38985431). 38985431
JAK3 V718L esophagus adenocarcinoma sensitive Momelotinib Preclinical - Patient cell culture Actionable In a preclinical study, Momelotinib (CYT387) inhibited viability of cells derived from the brain metastases of a patient with esophagus adenocarcinoma harboring JAK3 V718L in culture (PMID: 38985431). 38985431
JAK3 V718L esophagus adenocarcinoma sensitive Fedratinib Preclinical - Patient cell culture Actionable In a preclinical study, Inrebic (fedratinib) inhibited viability of cells derived from the brain metastases of a patient with esophagus adenocarcinoma harboring JAK3 V718L in culture (PMID: 38985431). 38985431