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Profile Name | CDKN2A R80* |
Gene Variant Detail | |
Relevant Treatment Approaches | CDK Inhibitor (Pan) CDK4 Inhibitor CDK4/6 Inhibitor CDK6 Inhibitor |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
CDKN2A R80* | stomach carcinoma | sensitive | CDK4/6 Inhibitor | Palbociclib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, a gastric carcinoma cell line harboring CDKN2A R80* was sensitive to Ibrance (palbociclib) both in culture and in cell line xenograft models (PMID: 26380006, PMID: 20952405). | 26380006 20952405 |