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| Profile Name | KEAP1 D236H |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| KEAP1 D236H | lung non-small cell carcinoma | resistant | Gefitinib | Preclinical - Cell culture | Actionable | In a preclinical study, the KEAP1 D236H mutation was identified in non-small cell lung cancer cells that acquired resistance to Iressa (gefitinib) in culture (PMID: 29812969). | 29812969 | |
| KEAP1 D236H | lung non-small cell carcinoma | resistant | Osimertinib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cells that acquired resistance to Iressa (gefitinib) harbored the KEAP1 D236H mutation and also demonstrated resistance to Tagrisso (osimertinib) in culture (PMID: 29812969). | 29812969 | |
| KEAP1 D236H | lung non-small cell carcinoma | resistant | Afatinib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cells that acquired resistance to Iressa (gefitinib) harbored the KEAP1 D236H mutation and also demonstrated resistance to Gilotrif (afatinib) in culture (PMID: 29812969). | 29812969 |