Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Profile Name | KEAP1 D236H |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
KEAP1 D236H | lung non-small cell carcinoma | resistant | Gefitinib | Preclinical - Cell culture | Actionable | In a preclinical study, the KEAP1 D236H mutation was identified in non-small cell lung cancer cells that acquired resistance to Iressa (gefitinib) in culture (PMID: 29812969). | 29812969 | |
KEAP1 D236H | lung non-small cell carcinoma | resistant | Osimertinib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cells that acquired resistance to Iressa (gefitinib) harbored the KEAP1 D236H mutation and also demonstrated resistance to Tagrisso (osimertinib) in culture (PMID: 29812969). | 29812969 | |
KEAP1 D236H | lung non-small cell carcinoma | resistant | Afatinib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cells that acquired resistance to Iressa (gefitinib) harbored the KEAP1 D236H mutation and also demonstrated resistance to Gilotrif (afatinib) in culture (PMID: 29812969). | 29812969 |