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| Profile Name | NTRK1 G613V |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| NTRK1 G613V | dedifferentiated liposarcoma | resistant | Larotrectinib | Preclinical - Cell culture | Actionable | In a preclinical study, a dedifferentiated liposarcoma cell line expressing NTRK1 G613V demonstrated resistance to Vitrakvi (larotrectinib) in culture (PMID: 38531265). | 38531265 | |
| NTRK1 G613V | dedifferentiated liposarcoma | resistant | Selitrectinib | Preclinical - Cell culture | Actionable | In a preclinical study, a dedifferentiated liposarcoma cell line expressing NTRK1 G613V demonstrated resistance to Selitrectinib (LOXO-195) in culture (PMID: 38531265). | 38531265 |