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| Molecular Profile | SMARCA4 mutant |
| Therapy | Tozasertib |
| Indication/Tumor Type | lung non-small cell carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SMARCA4 mutant | lung non-small cell carcinoma | predicted - sensitive | Tozasertib | Preclinical - Cell culture | Actionable | In a preclinical study, a non-small cell lung cancer cell line harboring a SMARCA4 mutation demonstrated sensitivity to Tozasertib (VX-680) in culture (Cancer Res July 15 2016 (76) (14 Supplement) LB-318). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Abstract LB-318: SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A-targeted therapies in non-small cell lung cancers (NSCLCs) | Full reference... |