Therapy Detail
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| Therapy Name | Tozasertib |
| Synonyms | |
| Therapy Description |
Tozasertib (VX-680) is a pan-AURK inhibitor with increased potency against Aurora kinase A (AURKA), and has additional activity against BCR-ABL, potentially resulting in decreased tumor growth (PMID: 14981513, PMID: 22772060, PMID: 32017040). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Tozasertib | MK-0457|VX-680 | AURK Inhibitor (Pan) 12 BCR-ABL Inhibitor 32 | Tozasertib (VX-680) is a pan-AURK inhibitor with increased potency against Aurora kinase A (AURKA), and has additional activity against BCR-ABL, potentially resulting in decreased tumor growth (PMID: 14981513, PMID: 22772060, PMID: 32017040). |
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| SMARCA4 loss | lung non-small cell carcinoma | sensitive | Tozasertib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung cancer cell lines with SMARCA4 loss demonstrated increased sensitivity to Tozasertib (VX-680), compared to cell lines expressing wild-type SMARCA4, in culture (Cancer Res July 15 2016 (76) (14 Supplement) LB-318). | detail... |
| SMARCA4 inact mut | lung non-small cell carcinoma | sensitive | Tozasertib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, non-small cell lung cancer cell lines harboring SMARCA4 inactivating mutations demonstrated sensitivity to Tozasertib (VX-680) in culture and in xenograft models (PMID: 28102363). | 28102363 |
| SMARCA4 mutant | lung non-small cell carcinoma | predicted - sensitive | Tozasertib | Preclinical - Cell culture | Actionable | In a preclinical study, a non-small cell lung cancer cell line harboring a SMARCA4 mutation demonstrated sensitivity to Tozasertib (VX-680) in culture (Cancer Res July 15 2016 (76) (14 Supplement) LB-318). | detail... |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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