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Molecular Profile PDGFRB positive
Therapy Imatinib
Indication/Tumor Type mixed epithelial stromal tumour
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PDGFRB positive mixed epithelial stromal tumour sensitive Imatinib Preclinical - Cell culture Actionable In a preclinical study, epithelial stromal tumor cells of the seminal vescicle from a prostate adenocarcinoma mouse model expressing PDGFRB demonstrated sensitivity to Gleevec (imatinib) in culture, resulting in inhibition of cell proliferation (PMID: 27980106). 27980106
PubMed Id Reference Title Details
(27980106) Imatinib Spares cKit-Expressing Prostate Neuroendocrine Tumors, whereas Kills Seminal Vesicle Epithelial-Stromal Tumors by Targeting PDGFR-β. Full reference...