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| Molecular Profile | TP53 wild-type |
| Therapy | Ceralasertib + Radiotherapy |
| Indication/Tumor Type | lung carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| TP53 wild-type | lung carcinoma | sensitive | Ceralasertib + Radiotherapy | Preclinical - Cell culture | Actionable | In a preclinical study, AZD6738 treatment increased sensitivity to radiotherapy in a lung carcinoma cell line harboring wild-type TP53 in culture, resulting in a greater decrease in cell survival compared to radiation treatment alone (PMID: 28062704). | 28062704 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28062704) | Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei. | Full reference... |