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Molecular Profile PIK3CA H1047R PTEN loss
Therapy ABT-737 + Dactolisib
Indication/Tumor Type triple-receptor negative breast cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA H1047R PTEN loss triple-receptor negative breast cancer predicted - sensitive ABT-737 + Dactolisib Preclinical - Cell line xenograft Actionable In a preclinical study, ABT-737 and BEZ235 combination treatment resulted in tumor regression in cell line xenograft models of triple-receptor negative breast cancer harboring PIK3CA H1047R and PTEN loss (PMID: 27974663). 27974663
PubMed Id Reference Title Details
(27974663) PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. Full reference...