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| Molecular Profile | RB1 loss |
| Therapy | Trichostatin A |
| Indication/Tumor Type | retinoblastoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| RB1 loss | retinoblastoma | sensitive | Trichostatin A | Preclinical - Cell culture | Actionable | In a preclinical study, Trichostatin A (TSA) inhibited growth of retinoblastoma cell lines in culture (PMID: 18483379), which have been demonstrated to be deficient in RB1 (PMID: 23498719). | 23498719 18483379 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (18483379) | Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma. | Full reference... |
| (23498719) | Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. | Full reference... |