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Molecular Profile RB1 loss
Therapy Trichostatin A
Indication/Tumor Type retinoblastoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RB1 loss retinoblastoma sensitive Trichostatin A Preclinical - Cell culture Actionable In a preclinical study, Trichostatin A (TSA) inhibited growth of retinoblastoma cell lines in culture (PMID: 18483379), which have been demonstrated to be deficient in RB1 (PMID: 23498719). 23498719 18483379
PubMed Id Reference Title Details
(18483379) Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma. Full reference...
(23498719) Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies. Full reference...