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ID | DOID:768 |
Name | retinoblastoma |
Definition | A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina. |
Source | DiseaseOntology.org |
Alt Ids | |
Path | disease disease of cellular proliferation cancer organ system cancer nervous system cancer sensory system cancer ocular cancer retinal cancer retinal cell cancer retinoblastoma |
Molecular Profile | Therapy | Indication/Tumor Type | Response Type | Profile Response Detail |
---|---|---|---|---|
RB1 loss | Sirolimus | retinoblastoma | sensitive | detail... |
RB1 inact mut | Fostamatinib | retinoblastoma | sensitive | detail... |
RB1 inact mut | BAY 61-3606 | retinoblastoma | sensitive | detail... |
RB1 inact mut | Nutlin-3a | retinoblastoma | sensitive | detail... |
RB1 loss | Trichostatin A | retinoblastoma | sensitive | detail... |
RB1 loss | Vorinostat | retinoblastoma | sensitive | detail... |
RB1 loss | Entinostat | retinoblastoma | sensitive | detail... |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT01331135 | Phase I | Sirolimus | Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors | Completed | USA | 0 |
NCT01661400 | Phase I | Cyclophosphamide Thalidomide | Anti-Angiogenic Therapy Post Transplant (ASCR) for Relapsed and Refractory Pediatric Solid Tumors | Completed | USA | 0 |
NCT01783535 | Phase II | Cyclophosphamide Carboplatin + Doxorubicin + Vincristine Sulfate Pegfilgrastim Topotecan + Vincristine Sulfate Carboplatin + Etoposide + Vincristine Sulfate Filgrastim Carboplatin + Topotecan Carboplatin + Vincristine Sulfate | Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma | Active, not recruiting | USA | 0 |
NCT02130869 | Phase I | Bendamustine + Cytarabine + Etoposide Busulfan + Hu14.18K322A Aldesleukin + Melphalan + Sargramostim Filgrastim Carboplatin + Etoposide | A Pilot Study of Immunotherapy Including Haploidentical NK Cell Infusion Following CD133+ Positively-Selected Autologous Hematopoietic Stem Cells in Children With High Risk Solid Tumors or Lymphomas | Completed | USA | 0 |
NCT03654716 | Phase I | ALRN-6924 + Cytarabine ALRN-6924 | Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer | Completed | USA | 0 |
NCT03860207 | Phase Ib/II | Hu3F8-BsAb | Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3F8-BsAb) in Patients With Relapsed/Refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers | Terminated | USA | 0 |
NCT05064306 | Expanded access | Omburtamab I-131 | 131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young Adults | Available | USA | 0 |