retinoblastoma
Disease Detail

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ID DOID:768
Name retinoblastoma
Definition A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.
Source DiseaseOntology.org
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ICDO:9510/3
SNOMEDCT_US_2023_03_01:154553002
Path disease disease of cellular proliferation cancer organ system cancer nervous system cancer sensory system cancer ocular cancer retinal cancer retinal cell cancer retinoblastoma

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
RB1 loss Sirolimus retinoblastoma sensitive detail...
RB1 inact mut Fostamatinib retinoblastoma sensitive detail...
RB1 inact mut BAY 61-3606 retinoblastoma sensitive detail...
RB1 inact mut Nutlin-3a retinoblastoma sensitive detail...
RB1 loss Trichostatin A retinoblastoma sensitive detail...
RB1 loss Vorinostat retinoblastoma sensitive detail...
RB1 loss Entinostat retinoblastoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01331135 Phase I Sirolimus Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors Completed USA 0
NCT01661400 Phase I Cyclophosphamide Thalidomide Anti-Angiogenic Therapy Post Transplant (ASCR) for Relapsed and Refractory Pediatric Solid Tumors Completed USA 0
NCT01783535 Phase II Cyclophosphamide Carboplatin + Doxorubicin + Vincristine Sulfate Pegfilgrastim Topotecan + Vincristine Sulfate Carboplatin + Etoposide + Vincristine Sulfate Filgrastim Carboplatin + Topotecan Carboplatin + Vincristine Sulfate Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma Active, not recruiting USA 0
NCT02130869 Phase I Bendamustine + Cytarabine + Etoposide Busulfan + Hu14.18K322A Aldesleukin + Melphalan + Sargramostim Filgrastim Carboplatin + Etoposide A Pilot Study of Immunotherapy Including Haploidentical NK Cell Infusion Following CD133+ Positively-Selected Autologous Hematopoietic Stem Cells in Children With High Risk Solid Tumors or Lymphomas Completed USA 0
NCT03654716 Phase I ALRN-6924 + Cytarabine ALRN-6924 Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer Completed USA 0
NCT03860207 Phase Ib/II Hu3F8-BsAb Study of the Safety and Efficacy of Humanized 3F8 Bispecific Antibody (Hu3F8-BsAb) in Patients With Relapsed/Refractory Neuroblastoma, Osteosarcoma and Other Solid Tumor Cancers Terminated USA 0
NCT05064306 Expanded access Omburtamab I-131 131I-omburtamab for the Treatment of Central Nervous System/Leptomeningeal Neoplasms in Children and Young Adults No longer available USA 0
NCT05650749 Phase I GPC2 CAR-T cells GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma (GPC2) Recruiting USA 0