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| Molecular Profile | ERBB3 mutant |
| Therapy | Cisplatin + Gemcitabine + Sorafenib |
| Indication/Tumor Type | invasive bladder transitional cell carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ERBB3 mutant | invasive bladder transitional cell carcinoma | predicted - sensitive | Cisplatin + Gemcitabine + Sorafenib | Phase II | Actionable | In a Phase II trial, ERBB3 mutations were only detected in patients with muscle-invasive urothelial bladder cancer that responded to Nexavar (sorafenib), Platinol (cisplatin) and Gemzar (gemcitabine) combination therapy (J Clin Oncol 35, 2017 (suppl 6S; abstract 345)). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Neoadjuvant sorafenib, gemcitabine, and cisplatin (SGC) for muscle-invasive urothelial bladder cancer (MIUBC): Final results and translational findings of an open-label, single-arm, phase II study. | Full reference... |