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| Molecular Profile | EML4 - ALK |
| Therapy | X-376 |
| Indication/Tumor Type | lung cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| EML4 - ALK | lung cancer | sensitive | X-376 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, X-376 inhibited Alk signaling, resulted in growth inhibition in lung cancer cells harboring EML4-ALK fusion in culture and in cell line xenograft models (PMID: 21613408). | 21613408 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21613408) | Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. | Full reference... |