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Molecular Profile | PTEN inact mut |
Therapy | Voxtalisib |
Indication/Tumor Type | glioblastoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PTEN inact mut | glioblastoma | sensitive | Voxtalisib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, a glioblastoma cell line harboring a PTEN inactivating mutation was sensitive to XL765 (SAR245409), demonstrating inhibition of cell proliferation in culture, and inhibition of tumor growth in cell line xenograft models (PMID: 24634413). | 24634413 |
PubMed Id | Reference Title | Details |
---|---|---|
(24634413) | Characterization of the activity of the PI3K/mTOR inhibitor XL765 (SAR245409) in tumor models with diverse genetic alterations affecting the PI3K pathway. | Full reference... |