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Molecular Profile | TP53 wild-type |
Therapy | ALRN-6924 |
Indication/Tumor Type | Merkel cell carcinoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 wild-type | Merkel cell carcinoma | predicted - sensitive | ALRN-6924 | Case Reports/Case Series | Actionable | In a Phase I trial, ALRN-6924 treatment in a patient with Merkel cell carcinoma resulted in a complete response (PMID: 34301750; NCT02264613). | 34301750 |
PubMed Id | Reference Title | Details |
---|---|---|
(34301750) | Phase 1 Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53. | Full reference... |