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Molecular Profile | FLT3 D835Y |
Therapy | Tretinoin |
Indication/Tumor Type | acute promyelocytic leukemia |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 D835Y | acute promyelocytic leukemia | predicted - resistant | Tretinoin | Case Reports/Case Series | Actionable | In a clinical case study, a patient with acute promyelocytic leukemia developed meningeal relapse after maintenance therapy with Vesanoid (tretinoin), which was found to be due to a FLT3 D835Y variant (PMID: 27626069). | 27626069 |
PubMed Id | Reference Title | Details |
---|---|---|
(27626069) | Evolution of a FLT3-TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia. | Full reference... |