acute promyelocytic leukemia
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ID DOID:0060318
Name acute promyelocytic leukemia
Definition An acute myeloid leukemia characterized by accumulation of promyelocytes in the bone marrow and by a translocation between chromosomes 15 and 17.
Source DiseaseOntology.org
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SNOMEDCT_US_2023_03_01:28950004
Path disease disease of cellular proliferation cancer organ system cancer hematologic cancer leukemia myeloid leukemia acute myeloid leukemia acute promyelocytic leukemia

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
FLT3 D835Y Arsenic trioxide + Cytarabine + Methotrexate + Tretinoin acute promyelocytic leukemia predicted - sensitive detail...
FLT3 D835Y Tretinoin acute promyelocytic leukemia predicted - resistant detail...
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT01409161 Phase II Arsenic trioxide + Gemtuzumab ozogamicin + Tretinoin Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia Recruiting USA 0
NCT01869803 Phase I Gemtuzumab ozogamicin Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Acute Promyelocytic Leukemia Approved for marketing USA 0
NCT02339740 Phase III Cytarabine + Dexamethasone + Idarubicin + Mitoxantrone Arsenic trioxide + Gemtuzumab ozogamicin + Tretinoin Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia Active, not recruiting USA | NZL | CAN | AUS 2
NCT02688140 Phase III Arsenic trioxide + Idarubicin + Tretinoin Mercaptopurine + Methotrexate + Tretinoin Cytarabine + Idarubicin + Tretinoin Mitoxantrone + Tretinoin Idarubicin + Tretinoin Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia (TUD-APOLLO-064) Completed NLD | ITA | FRA | ESP | DEU 0
NCT03674411 Phase II Busulfan + Filgrastim + Fludarabine + Melphalan + MGTA-456 + Mycophenolate mofetil + Tacrolimus Cyclophosphamide + Filgrastim + Fludarabine + MGTA-456 + Mycophenolate mofetil + Tacrolimus Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy Active, not recruiting USA 0
NCT04793919 Phase II Arsenic trioxide + Gemtuzumab ozogamicin + Tretinoin Arsenic trioxide + Tretinoin Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia Recruiting SWE | NLD | ITA | ISR | IRL | FRA | ESP | DNK | DEU | CZE | BEL 1
NCT04996030 Phase I Arsenic trioxide + SY-2101 SY-2101 Arsenic trioxide A Study for Oral SY-2101 for Participants With Acute Promyelocytic Leukemia Suspended USA 0
NCT06199557 Phase Ib/II Mercaptopurine + Valproic acid Hydroxyurea + Valproic acid Valproic acid A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-MDS Patients (HUVAMER) Recruiting NOR 0