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| Molecular Profile | PTEN loss |
| Therapy | Dactolisib |
| Indication/Tumor Type | head and neck squamous cell carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PTEN loss | head and neck squamous cell carcinoma | predicted - sensitive | Dactolisib | Preclinical - Cell culture | Actionable | In a preclinical study, BEZ235 resulted in antiproliferative activity in head and neck squamous cell carcinoma cells harboring PTEN loss in culture (PMID: 28446642). | 28446642 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28446642) | Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC. | Full reference... |