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| Molecular Profile | PIK3CA act mut |
| Therapy | AZD8055 + Cetuximab |
| Indication/Tumor Type | head and neck squamous cell carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA act mut | head and neck squamous cell carcinoma | predicted - sensitive | AZD8055 + Cetuximab | Preclinical - Pdx | Actionable | In a preclinical study, two head and neck squamous cell carcinoma patient-derived xenograft (PDX) models harboring a PIK3CA activating mutation demonstrated greater delayed tumor growth when treated with a combination of AZD8055 and Erbitux (cetuximab) compared to either agent alone (PMID: 28446642). | 28446642 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28446642) | Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC. | Full reference... |