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| Molecular Profile | MDM2 amp |
| Therapy | Pembrolizumab |
| Indication/Tumor Type | triple-receptor negative breast cancer |
| Response Type | no benefit |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MDM2 amp | triple-receptor negative breast cancer | no benefit | Pembrolizumab | Case Reports/Case Series | Actionable | In a clinical case study, a patient with triple-receptor negative breast cancer that harbored MDM2 amplification quickly progressed after receiving Keytruda (pembrolizumab), resulted in new chest wall metastasis and a 55% increase of existing lung metastasis size 1.5 months after treatment (PMID: 28351930). | 28351930 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (28351930) | Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate. | Full reference... |