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Molecular Profile | TP53 A159V |
Therapy | Seliciclib |
Indication/Tumor Type | lung non-small cell carcinoma |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
TP53 A159V | lung non-small cell carcinoma | decreased response | Seliciclib | Preclinical - Cell culture | Actionable | In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 A159V demonstrated reduced sensitivity to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161). | 22862161 |
PubMed Id | Reference Title | Details |
---|---|---|
(22862161) | Roscovitine-induced apoptosis of H1299 cells depends on functional status of p53. | Full reference... |