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Therapy Name	Seliciclib
Synonyms
Therapy Description	Roscovotine (seliciclib) inhibits Cdc2, Cdk2 and Cdk5, which results in disruption of cell-cycle progression and decreased cell proliferation (PMID: 9030781, PMID: 9366565, PMID: 20822897)

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Seliciclib		Roscovitine\|CYC202	CDK2 Inhibitor 31 CDK5 Inhibitor 8	Roscovotine (seliciclib) inhibits Cdc2, Cdk2 and Cdk5, which results in disruption of cell-cycle progression and decreased cell proliferation (PMID: 9030781, PMID: 9366565, PMID: 20822897)

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
TP53 A159V	lung non-small cell carcinoma	decreased response	Seliciclib	Preclinical - Cell culture	Actionable	In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 A159V demonstrated reduced sensitivity to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161).	22862161
TP53 negative	lung non-small cell carcinoma	decreased response	Seliciclib	Preclinical - Cell culture	Actionable	In a preclinical study, TP53-null non-small cell lung carcinoma cells demonstrated reduced sensitivity to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161).	22862161
TP53 P98A	lung non-small cell carcinoma	decreased response	Seliciclib	Preclinical - Cell culture	Actionable	In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 P98A demonstrated reduced sensitivity to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161).	22862161
TP53 R175H	lung non-small cell carcinoma	resistant	Seliciclib	Preclinical - Cell culture	Actionable	In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 R175H were resistant to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161).	22862161
TP53 S215G	lung non-small cell carcinoma	resistant	Seliciclib	Preclinical - Cell culture	Actionable	In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 S215G were resistant to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161).	22862161
TP53 wild-type	lung non-small cell carcinoma	sensitive	Seliciclib	Preclinical - Cell culture	Actionable	In a preclinical study, Roscovotine (seliciclib) induced substantial apoptosis in non-small cell lung carcinoma cells overexpressing wild-type TP53 in culture (PMID: 22862161).	22862161
TP53 Y220C	lung non-small cell carcinoma	resistant	Seliciclib	Preclinical - Cell culture	Actionable	In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 Y220C were resistant to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161).	22862161
TP53 Y234C	lung non-small cell carcinoma	decreased response	Seliciclib	Preclinical - Cell culture	Actionable	In a preclinical study, non-small cell lung carcinoma cells overexpressing TP53 Y234C demonstrated reduced sensitivity to Roscovotine (seliciclib) induced apoptosis in culture (PMID: 22862161).	22862161

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